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MsEleanor
1--164 ce had a small pox epidemic which contributed to the decline of the Roman Empire

2--1347 ce was the height of the Black Plague contributing to population declines in Europe

3--1492 ce was the onset of small pox and other diseases entering the America decimating the population of the native populations.

The similarity between all three time periods is a period of disease which led to great numbers of population decline. 

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